Neuronal Disorders
A feature assay in our Neuronal Disorders product line is the Myelin Basic Protein (MBP) immunoassay. MBP comprises approximately 30% of the myelin sheath in the central nervous system (CNS) and 10% of peripheral nervous system (PNS) tissues. It has important roles in myelination and structural integrity of nervous system tissues. Conditions associated with demyelination and degeneration of the myelin sheath result in high concentrations of MBP fragments in the cerebrospinal fluid (CSF). The Ansh Labs development team has years of experience investigating this protein and has developed monoclonal antibodies, stable calibrators, and reliable assays to sensitively and specifically measure the specific fragments of myelin basic protein in CSF.
* Unless otherwise stated in our catalog or other product documentation, these kits are intended for research use only and not for in vitro diagnostic purposes or therapeutic uses.
Role of IGFs in the Central Nervous System?
Puche and Larrea observed:
(1) IGF-I actions, taken together with its neuroprotective effects following CNS and peripheral nerve injury, suggest that it may be of therapeutic benefit in a wide variety of disorders affecting the nervous system.
(2) Little is known about those factors and mechanisms that regulate IGF-I expression in the brain, but there is evidence, however, that growth factors, nutrition, and injury, influence in vivo brain expression.
Reference: J Transl Med. 2012; 10: 224.
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