The PLGF enzyme linked immunosorbent assay (ELISA) kit provides materials for the quantitative measurement of PLGF in serum and other biological fluids.
| Catalog Number | AL-1008-r (RUO) Instructions for Use |
|---|---|
| Regulatory Status | For in vitro diagnostic use within the United States. CE mark version for international markets. |
| Packaging | 96 well microtiter |
| Detection | HRP-based ELISA, colorimetric detection by dual wavelength absorbance at 450 nm and 630 nm as reference filter |
| Dynamic Range | 6, 3.4-625 pg/mL |
| Limit of Detection | 2.1 pg/mL |
| Sample Size | 50 µL |
| Sample Type | Serum |
| Assay Time | 1.5 hours |
| Species Reactivity | Bovine, Caprine, Equine, Ovine, Porcine, Rabbit |
| Shelf Life | 24 months |
| Availability | Worldwide |
Placental growth factor (PLGF) is a member of PDGF/VEGF family growth factors. PLGF, a member of VEGF family, is produced mainly by placenta and is normally found in urine and blood during pregnancy. Angiogenesis and vascular transformation are important processes in the normal development of the placenta. Abnormal angiogenesis and vascular transformation are considered one of the main reasons for preeclamptic pregnancies and intrauterine growth retardation. In pre-eclampsia, there is increased expression of soluble fms-like tyrosine kinase-1 (sFlt1) which binds to circulating PLGF. Consequently, concentrations of plasma PLGF are found to be decreased in pregnant women with pre-eclampsia.