The MenoCheck picoAMH ELISA is FDA cleared for in vitro diagnostic use as an aid in the determination of menopausal status in women between 42 and 62 years of age. This is the only AMH test with the sensitivity to quantify declining AMH concentrations in women who are entering their menopausal transition.
Research Use Only and CE versions are available.
Catalog Numbers | AL-124 (FDA) Instructions For Use |
---|---|
Packaging | 96 well microtiter |
Detection | HRP-based ELISA, colorimetric detection by dual wavelength absorbance at 450 nm and 630 nm as reference filter |
Dynamic Range | 6, 7.6-1091 pg/mL |
Species Reactivity | Enquire about animal-specific cross-reactivity |
Limit of Detection | 1.3 pg/mL |
Sample Size | 100 µL |
Sample Type | Serum |
Assay Time | 4.5 hours |
Shelf Life | 24 months |
Menopause is the cessation of menstrual cycling and fertility. Clinically it is recognized by a cessation of menstrual bleeding; menopause is a woman’s status after her final menstrual period (FMP). Menstrual cycling and bleeding are driven by the dynamics of ovarian follicle maturation. Because a woman is born with a limited number of follicles (non-growing “primodial” follicles) that cannot be replaced and are slowly consumed by the monthly maturation of smaller groups of follicles (primary, secondary and antral growing follicles), the natural cause of menopause is the absence of follicles. However, many natural (e.g., certain diseases, starvation, etc.) or interventional processes (chemotherapy, surgical removal of the uterus, ovaries, or pituitary gland, etc.) can cause a cessation of menses that can be either irreversible (e.g., functionally the same as menopause) or reversible. Diagnosing menopause (e.g. the FMP) currently is only done unequivocally after cessation of menses for 12 months in a previously cycling woman.
Naturally occurring (i.e., as a result of aging) menopause is referred to as “spontaneous” and, on average, occurs at the age of 51 years, but there is a very large variance of approximately +/- 10 years with respect to the occurrence of menopause in healthy women. Ovarian function deteriorates gradually leading up to menopause and contributes to the variance observed among women with respect to menopausal status. Ovarian function affects, primarily via the steroid hormones produced by growing follicles, virtually every organ in a woman’s body. Physiological responses to the gradual or abrupt loss of ovarian function include a multitude of menopausal “symptoms” and consequences that affect a woman’s health and quality of life. 1,2
During several years leading up to the FMP and several years immediately following the FMP is a time called the climacteric or menopausal transition, when a woman transitions from the reproductive to a non-reproductive state. The transition is highly variable among women with respect to duration and intensity of associated physiological changes, which affect her well being and level of disease risk. Thus, determining where a woman is in this process must be individualized and is clinically important, particularly during the menopausal transition and the 12 months following the FMP. Quantitative measurement of blood levels of Anti-Müllerian Hormone using the picoAMH assay can aid in determining a woman’s menopausal status during the menopausal transition.
Blood levels of AMH represent one of the markers available to clinicians to determine where a woman is in her menopausal transition. Other clinical tests relevant in this context are estradiol which is produced only by follicles in their final stages of maturation, and thus only indirectly reflects the total number of follicles in the ovary, and FSH which reflects the negative feedback by estradiol on pituitary gland secretion (i.e., also an indirect marker of ovarian follicular pool based on large follicle function). In contrast AMH is produced by the majority of ovarian follicles (primary, secondary and antral).
Blood levels of AMH have been shown to be highly correlated with the number of primordial follicles in an ovary (i.e., true ovarian reserve).3 The picoAMH assay was developed to allow more sensitive measurements. AMH measured using the picoAMH assay provides a significant new parameter to aid physicians in determining the status of women during the menopausal transition.
REFERENCES
1. Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen RJ 2015 Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 100:3975-4011
2. Su HI, Freeman EW 2009 Hormone changes associated with the menopausal transition. Minerva Ginecol 61:483-489
MenoCheck ELISA (Also known as picoAMH ELISA)
AMH (MenoCheck) (pico) ELISA AL-124
Finkelstein JS, Lee H, Karlamangla A, Neer RM, Sluss PM, Burnett-Bowie SA, Darakananda K, Donahoe PK, Harlow SD, Prizand SH, Joffe H, Kumar A, Martin DE, McConnell D, Merrilat S, Morrison A, Pastore LM, Randolph JF, Greendale GA, Santoro N. Antimullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women’s Health Across the Nation. The Journal of Clinical Endocrinology & Metabolism, Volume 105, Issue 4, April 2020, Pages e1862–e1871, https://doi.org/10.1210/clinem/dgz283
All Products Cited: AMH (MenoCheck) (pico) ELISA AL-124; Inhibin B ELISA AL-107
Sluss PM, Palomaki G, Kumar A, Morrison A, Kalra B, Alpadi K. Analytical Performance and Clinical Value of AMH Testing. J Endocr Soc. 2020 May 8; 4(Suppl 1): SAT-016.Published online 2020 May 8. doi: 10.1210/jendso/bvaa046.1970
All Products Cited: AMH (MenoCheck) (pico) ELISA AL-124
AMH (pico) ELISA AL-124
Anderson C, Mark Park YM, Stanczyk FZ, Sandler DP, Nichols HB. Dietary factors and serum Anti-Mullerian hormone concentrations in late premenopausal women. Fertil Steril. 2018 Nov;110(6):1145-1153. doi: 10.1016/j.fertnstert.2018.06.037
All Products Cited: AMH (pico) ELISA AL-124
Anderson RA, Su HI. The Clinical Value and Interpretation of Anti-Müllerian Hormone in Women With Cancer. Front Endocrinol (Lausanne). 2020 Oct 7;11:574263. doi: 10.3389/fendo.2020.574263. PMID: 33117288; PMCID: PMC7577190.
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Barad D, Kushnir V, Khanna P, Gleicher N. Clinical in Vitro Fertilization (IVF) Outcomes Based on Comparative Anti-Müllerian Hormone (AMH) Testing with a Standard and New Highly Sensitive Assay. Poster session presented at: Endocrine Society’s 96th Annual Meeting; 2014; June 21-24; Chicago, IL.
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Barbagallo F, van der Ham K, Willemsen SP, Louwers YV, Laven JS. Age-related curves of AMH using the Gen II, the picoAMH, and the Elecsys assays in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2024;00(00):1-10. doi:10.1210/clinem/dgae153.
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Bertone-Johnson ER, Manson JE, Purdue-Smithe AC, Steiner AZ, Eliassen AH, Hankinson SE, Rosner BA, Whitcomb BW. Anti-Müllerian hormone levels and incidence of early natural menopause in a prospective study. Hum Reprod. 2018 Jun 1;33(6):1175-1182.
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Bertrand KA, Baer HJ, Orav EJ, Klifa C, Kumar A, Hylton NM, LeBlanc ES, Snetselaar LG, Van Horn L, Dorgan JF. Early life body fatness, serum antimüllerian hormone and breast density in young adult women. Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1151-7. doi: 10.1158/1055-9965.EPI-16-0185
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Broer SL, Broekmans FJM, Laven JSE, Fauser BCJM. Anti-Müllerian hormone: ovarian reserve testing and its potential clinical implications. Hum. Reprod. Update. 2014 May 12.
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Brouwer J, Dolhain RJEM, Hazes JMW, Erler NS, Visser JA, Laven JSE. . Decline of ovarian function in patients with rheumatoid arthritis: serum anti Müllerian hormone levels in a longitudinal cohort. RMD Open. 2020 Oct;6(3):e001307. doi: 10.1136/rmdopen-2020-001307
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Brouwer J, Dolhain RJEM, Hazes JMW, Visser JA, Laven JSE. Reduced Ovarian Function in Female Rheumatoid Arthritis Patients Trying to Conceive. ACR Open Rheumatol 2019 Jul 4;1(5):327-335. doi: 10.1002/acr2.11043. eCollection 2019 Jul.
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Buckbinder J, Mucowski S, Burks H, Stanczyk F, Hodis H, Mack W, Bendikson K, Shoupe D. The Detection and Clinical Utilization of Anti-Mullerian Hormone (AMH) in Postmenopausal Women Using the New Highly Sensitive ELISA. Poster session at American Society for Reproductive Medicine; 2015 Oct 17-21; Baltimore, Maryland
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Bungum L, Tagevi J, Jokubkiene L, Bungum M, Giwercman A, Macklon N, Andersen CY, Klausen TW, Torring N, Kumar A, Skouby SO. The Impact of the Biological Variability or Assay Performance on AMH Measurements: A Prospective Cohort Study With AMH Tested on Three Analytical Assay-Platforms. Front. Endocrinol., 16 October 2018.
All Products Cited: AMH ELISA AL-105; AMH (pico) ELISA-124
Burks H, Ross L, Opper N, Stancyzk F. Can Ultrasensitive Anti-Mullerian Hormone Testing Predict Failed Response to Ovarian Stimulation? . PCRS Abstracts Vol. 101, No. 2, Supplement, February 2014
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Burks HR, Ross L, Opper N, Paulson E, Stanczyk F, Chung K. Can highly sensitive antimullerian hormone testing predict failed response to ovarian stimulation? . Fertility and Sterility. 2015 Sep; 104(3):643-648.
All Products Cited: AMH ELISA AL-105; AMH (pico) ELISA AL-124
Caanen MR, Peters HE, van de Ven PM, Jüttner AMFM, Laven JSE, van Hooff MHA, Lambalk CB. Anti-Müllerian Hormone Levels in Adolescence in Relation to Long-term Follow-up for Presence of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1084-e1095. doi: 10.1210/clinem/dgaa949. PMID: 33351079; PMCID: PMC7947839
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Cameron K, Sammel MD, Prewitt M, Gracia C. Differential Rates of Change in Measures of Ovarian Reserve in Young Cancer Survivors Across the Reproductive Lifespan. J Clin Endocrinol Metab. 2019 May 1;104(5):1813-1822. doi: 10.1210/jc.2018-02257. PMID: 30566616; PMCID: PMC6456010.
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Chai J, Howie F, Cameron DA, Anderson, RA. Analysis of ovarian function following chemotherapy for early breast cancer using an ultra-sensitive assay. Poster session presented at: European Society for Human Reproduction and Embryology; 2014, Jun 29 – July 2 Munich, Germany.
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Clendenen TV, Ge W, Koenig KL, Afanasyeva Y, Agnoli C, Bertone-Johnson E, Brinton LA, Darvishian F, Dorgan JF, Eliassen AH, Falk RT, Hallmans G, Hankinson SE, Hoffman-Bolton J, Key TJ, Krogh V, Nichols HB, Sandler DP, Schoemaker MJ, Sluss PM, Sund M, Swerdlow AJ, Visvanathan K, Liu M, Zeleniuch-Jacquotte A. Breast Cancer Risk Factors and Circulating Anti-Müllerian Hormone Concentration in Healthy Premenopausal Women. The Journal of Clinical Endocrinology & Metabolism, Volume 106, Issue 11, November 2021, Pages e4542–e4553
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Clendenen TV, Ge W, Koenig KL, Afanasyeva Y, Agnoli C, Brinton LA, Darvishian F, Dorgan JF, Eliassen AH, Falk RT, Hallmans G, Hankinson SE, Hoffman-Bolton J, Key TJ, Krogh V, Nichols HB, Sandler DP, Schoemaker MJ, Sluss PM, Sund M, Swerdlow AJ, Visvanathan K, Zeleniuch-Jacquotte A, Liu M. Breast cancer risk prediction in women aged 35-50 years: impact of including sex hormone concentrations in the Gail model. Breast Cancer Res. 2019 Mar 19;21(1):42.
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Cordeiro Mitchell, C.N., McGuinness, B., Fine, E. et al. Navigating the body of literature assessing BRCA1/2 mutations and markers of ovarian function: a systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics volume 37, pages1037–1055 (2020)
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de Kat AC, van der Schouw YT, Eijkemans MJ, Herber-Gast GC, Visser JA, Verschuren WM, Broekmans FJ. Back to the basics of ovarian aging: a population-based study on longitudinal anti-Müllerian hormone decline. BMC Med. 2016 Oct 3;14(1):151.
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de Kat AC, van der Schouw YT, Eijkemans MJC, Broer SL, Verschuren WMM, Broekmans FJM. Can menopause prediction be improved with multiple AMH measurements? Results from the prospective Doetinchem Cohort Study. J Clin Endocrinol Metab. 2019 Apr 22. pii: jc.2018-02607.
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De Kat AC, van der Schouw YT, Eijkemans MJC, Herber-Gast GC, Visser JA, Verschuren WMM, Broekmans FJM. Back to the basics of ovarian aging: a population-based study on longitudinal anti-Müllerian hormone decline. BMC Medicine. 2016;14:151.
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Ding N, Zheutlin E, Harlow SD, Randolph JF Jr, Mukherjee B, Park SK. Associations between repeated measures of urinary phthalate metabolites with hormones and timing of natural menopause. J Endocr Soc. 2023;7(4):1-11. doi:10.1210/jendso/bvad024.
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DiPrisco B, Kumar A, Kalra B, Savjani GV, Michael Z, Farr O, Papathanasiou AE, Christou H, Mantzoros CS. Glycosylated Fibronectin and Inhibin are Lower and Anti-Müllerian Hormone is Higher in Umbilical Cord Blood when Mothers have Preeclampsia. Endocr Pract. 2020 Mar;26(3):318-327. doi: 10.4158/EP-2019-0448. Epub 2019 Dec 20. PMID: 31859547.
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Drechsel KCE, Broer SL, Stoutjesdijk FS, Twisk JWR, van den Berg MH, Lambalk CB, et al. Clinical and self-reported markers of reproductive function in female survivors of childhood Hodgkin lymphoma. J Cancer Res Clin Oncol. 2023;149(13677–13695). doi:10.1007/s00432-023-05035-z.
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Dykgraaf RHM, Schalekamp-Timmermans S, Adank MC, van den Berg SAA, van de Lang-Born BMN, Korevaar TI, Kumar A, Kalra B, Savjani GV, Steegers EAP, Louwers YV, Laven JSE. Reference ranges of AMH and interaction with placental biomarkers in early pregnancy: the Generation R Study, a population-based prospective cohort study. Endocr Connect. 2022 Dec 1:EC-22-0320. doi: 10.1530/EC-22-0320. Epub ahead of print. PMID: 36524811.
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El Khoudary SR, Wang L, Brooks MM, Matthews KA, Thurston RC, Crawford S, Derby C, Jackson EA, Lee JS, Un-Yong Chae C, McConnell DS, Finkelstein J. Associations of Anti-Mullerian Hormone Premenopausal Levels and Their Changes over the Menopausal Transition with Lipids: The Study of Women′s Health Across the Nation (SWAN). Presented at 98th Annual Endocrine Society Meeting; 2016 Apr 1-3; Boston, MA
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Ferguson J, Hockley J, Rigsby P, Burns C. Establishment of a WHO Reference Reagent for anti-Mullerian hormone. Ferguson et al. Reproductive Biology and Endocrinology (2020) 18:86 https://doi.org/10.1186/s12958-020-00641-9
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Finkelstein JS, Lee H, Burnett-Bowie SAM, Santoro N, Yu EW, Joffe H, Morrison A, Kumar A, Greendale GA, Gold E, Harlow S, Lasley BL, Derby C, Randolph JF, Matthews KA, Kravitz HM, McConnell DS, Brooks MM, Martin D, Darakananda K, Hirsch SC, Sluss PM. Utility of Anti-Mullerian Hormone (AMH) for Predicting the Time to the Final Menstrual Period: The Study of Women’s Health Across the Nation (SWAN). Presented at 98th Annual Endocrine Society Meeting; 2016 Apr 1-3; Boston, MA
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Garnett ER, Jariwala P, Rector K, Gibbons WE, Zarutskie PW, Devaraj S. Validation of the picoAMH assay on the Dynex DS2 platform. Pract Lab Med. 2019;17. doi:10.1016/j.plabm.2019.e00140.
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Ge W, Clendenen TV, Afanasyeva Y, Koenig KL, Agnoli C, Brinton LA, Dorgan JF, Eliassen AH, Falk RT, Hallmans G, Hankinson SE, Hoffman-Bolton J, Key TJ, Krogh V, Nichols HB, Sandler DP, Schoemaker MJ, Sluss PM, Sund M, Swerdlow AJ,, Visvanathan K,, Liu M,, Zeleniuch-Jacquotte A. Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts. Int J Cancer. 2018 Jun 1;142(11):2215-2226.
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Giuliani E, Waldo A, Bernardi L, Carnethon M, Neff L, Marsh E. Gravidity, Parity, Breastfeeding, and AMH: Findings from the Ovarian Aging and Reserve Study (SOAR). Fertility and Sterility Abstract, Volume 114, Issue 3, Supplement E88, September 01, 2020
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Golenbock SW, Wise LA, Lambert-Messerlian GM, Eklund EE, Harlow BL. Association between a history of depression and anti-müllerian hormone among late-reproductive aged women: the Harvard study of moods and cycles. Womens Midlife Health. 2020 Sep 1;6:9. doi: 10.1186/s40695-020-00056-x. PMID: 32884826; PMCID: PMC7461252.
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Grynnerup G, Løssl K, Pilsgaard F, Lunding S, Storgaard M, Bogstad J, Prætorius L, Zedeler A , Bungum L , Nyboe A, Pinborg A. Prediction of the lower serum anti Müllerian hormone threshold for ovarian stimulation prior to in-vitro fertilization using the Elecsys AMH assay: a prospective observational study. Grynnerup et al. Reproductive Biology and Endocrinology (2019) 17:11 https://doi.org/10.1186/s12958-019-0452-4
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Hawkins Bressler L, Bernardi LA, De Chavez PJ, Baird DD, Carnethon MR, Marsh EE. Alcohol, cigarette smoking, and ovarian reserve in reproductive age African-American women. Am J Obstet Gynecol. 2016 Dec;215(6):758.e1-758.e9. doi: 10.1016/j.ajog.2016.07.012
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Hoyos LR, Visser JA, McLuskey A, Chazenbalk GD, Grogan TR, Dumesic DA. Loss of Antimullerian hormone immunoreactivity due to a homozygous AMH gene mutation Rs10417628 in a woman with classical polycystic ovary syndrome. J Endocr Soc. 2020;4(Supplement_1). doi:10.1210/jendso/bvaa046.
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Huddleston H, Santoro N, Eisenberg E, Haisenleder DJ, Diamond MP, Cedars M. Can We Expect to Improve Age at Menopause Predictions with Repeated AMH Measurements. Poster session at American Society for Reproductive Medicine; 2016 Oct 17-21; Salt Lake City, Utah.
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Iliodromiti S, Anderson RA, Nelson SM. Technical and performance characteristics of anti-Müllerian hormone and antral follicle count as biomarkers of ovarian response. Hum Reprod Update. 2015 Nov-Dec;21(6):698-710.
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Iwase A, Nakamura T, Nakahara T, Goto M, Kikkawa F. Anti-Mullerian Hormone and Assessment of Ovarian Reserve After Ovarian Toxic Treatment, a Systematic Narrative Review. Reproductive Sciences. 2015 May, 22(5):519-26.
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Iwase A, Nakamura T, Osuka S, Takikawa S, Goto M, Kikkawa F. Anti-Müllerian hormone as a marker of ovarian reserve: What have we learned, and what should we know?. Reprod Med Biol (2016) 15:127–136
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Iwase A, Osuka S, Nakamura T, Kato N, Takikawa S, Goto M, Kikkawa. Usefulness of the Ultrasensitive Anti-Mullerian Hormone Assay for Predicting True Ovarian Reserve. Reproductive Sciences, 2015, 1-5.
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Joffe H, Crawford S, Bromberger JT, Kalra B, Kumar A, Morrison A, Finkelstein J, Kravitz JM. Vasomotor Symptoms Mediate the Association Between Anti-Mullerian Hormone Levels and New-Onset Sleep Disturbance in Women during the Menopause Transition: Study of Women’s Health Across the Nation (SWAN). Presented at 98th Annual Endocrine Society Meeting; 2016 Apr 1-3; Boston, MA
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Johnson L, Sammel MD, Domchek S, Schanne A, Prewitt M, Gracia C. Antimüllerian hormone levels are lower in BRCA2 mutation carriers. Fertil Steril. 2017 May;107(5):1256-1265.e6.
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Jones BY, Bell HV, et al. Impact of a hypocaloric dietary intervention on antral follicle dynamics in eumenorrheic women with obesity. Hum Reprod. 2024 Feb 9;deae017. doi: 10.1093/humrep/deae017.
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Jung S, Allen N, Arslan AA, Baglietto L, Barricarte A, Brinton LA, Egleston BL, Falk RT, Fortner RT, Helzlsouer KJ, Gao Y, Idahl A, Kaaks R, Krogh V, Merritt MA, Lundin E, Onland-Moret NC, Rinaldi S, Schock H, Shu XO, Sluss PM, Staats PN, Sacerdote C, Travis RC, Tjønneland A, Trichopoulou A, Tworoger SS, Visvanathan K, Weiderpass E, Zeleniuch-Jacquotte A, Dorgan JF. Anti-Müllerian Hormone and risk of ovarian cancer in nine cohorts. Int J Cancer. 2017 Sep 18.
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Jung S, Allen N, Arslan AA, Baglietto L, Brinton LA, Egleston BL, Falk R, Fortner RT, Helzlsouer KJ, Idahl A, Kaaks R, Lundin E, Merritt M, Onland-Moret C, Rinaldi S, Sánchez MJ, Sieri S, Schock H, Shu XO, Sluss PM, Staats PN, Travis RC, Tjønneland A, Trichopoulou A, Tworoger S, Visvanathan K, Krogh V, Weiderpass E, Zeleniuch-Jacquotte A, Zheng W, Dorgan JF. Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women. Fertil Steril. 2017 Apr;107(4):1012-1022.e2.
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Karlamangla AS, Shieh A, Burnett-Bowie SA, Yu EW, Greendale GA, Sluss PM, Martin D, Finkelstein JS. Anti-Mullerian Hormone and Prediction of Trans-Menopausal Bone Loss. Presented at 98th Annual Endocrine Society Meeting; 2016 Apr 1-3; Boston, MA
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Karlamangla AS, Shieh A, Greendale GA, Yu EW, Burnett-Bowie SM, Sluss PM, Martin D, Morrison A, Finkelstein JS. Anti-Mullerian Hormone as Predictor of Future and Ongoing Bone Loss During the Menopause Transition. J Bone Miner Res. 2022 Jul;37(7):1224-1232. doi: 10.1002/jbmr.4525.
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Karlamangla AS. Anti-Mullerian hormone may estimate magnitude of menopausal bone loss. 2016 April 1. Retrieved from http://www.healio.com/endocrinology/bone-mineral-metabolism/news/online/%7B4f8e49d7-e1e8-4567-bdca-dd7d018f7fea%7D/anti-mullerian-hormone-may-estimate-magnitude-of-menopausal-bone-loss .
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Kohn SA, Fought AJ, Kuhn K, Slogett KJ, Bradford AP, Santoro N, Schauer I. Heparin effects on serum gonadotropins. J Endocr Soc. 2022;6(1):1-7. doi:10.1210/jendso/bvab178.
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Kopp DM, Wilkinson J, Bengtson A, Chipungu E, Pope RJ, Moyo M, Tang JH. Fertility outcomes following obstetric fistula repair: a prospective cohort study. Kopp et al. Reproductive Health (2017) 14:159 DOI 10.1186/s12978-017-0415-1
All Products Cited: AMH ELISA AL-105; AMH (pico) ELISA AL-124
Kristensen SG, Kumar A, Kalra B, Pors SE, Bøtkjær JA, Mamsen LS, Colmorn LB, Fedder J, Ernst E, Owens LA, Hardy K, Franks S, Andersen CY. Quantitative Differences in TGF-β Family Members Measured in Small Antral Follicle Fluids From Women With or Without PCO. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6371-6384. doi: 10.1210/jc.2019-01094. PMID: 31287539.
All Products Cited: GDF-9 ELISA AL-179; AMH (pico) ELISA AL-124; Inhibin-A ELISA AL-123; Inhibin-B ELISA AL-107; Inhibin (Total) ELISA AL-134; Activin-A ELISA AL-110; Activin-B ELISA AL-150; Activin AB ELISA AL-153; Follistatin ELISA AL-117; FTSL-3 ELISA AL-152
Kumar A, Kalra B, Patel A, Shah S, Savjani G, Themmen A, Visser J, Pruysers, Robertson D. Development of Stable picoAnti-Müllerian Hormone ELISA: Sensitive, Reliable and Reproducible Results. Poster session presented at the 96th Annual Endocrine Society Meeting; 2014 Jun 21-24; Chicago, IL.
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Kumar T, Chauhan R, Kalra B, Patel AS, Chauhan S, Kumar A. Novel comparative analysis of dried blood spot and serum ELISAs for AMH, FSH, and LH in patients seeking IVF treatment. J Endocr Soc. 2019;3(Supplement_1)
All Products Cited: AMH (pico) ELISA AL-124; DBS AMH ELISA AL-129; DBS LH ELISA AL-190; DBS FSH ELISA AL-187
L Melado Vidales, B Lawrenz, A Kumar, B Kalra, B Ata, R Patel, E Kalafat, R Loja Vitorino, I ElKhatib, H Fatemi, O-067 Does the measurement of different AMH isoforms in poor responder patients improve the prediction of ovarian response?, Human Reproduction, Volume 38, Issue Supplement_1, June 2023, dead093.081, https://doi.org/10.1093/humrep/dead093.081
All Products Cited: AMH (PCOCheck) ELISA AL-196; AMH (pico) ELISA AL-124; AMH ELISA AL-105; AMH (Total Mature) ELISA AL-133
LambertMesserlian G. The New Egg Timer – AntiMullerian Hormone Levels for Assessing Ovarian Reserve. Clinical Laboratory News. Jan 2015:14-18.
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Lu J, Holt C, Choi M, Kalp K, Straseski J. Quantitation of Anti-Müllerian Hormone by the AnshLabs picoAMH ELISA Assay. Poster session presented at American Association for Clinical Chemistry; 2014 Jul 27-31; Chicago, IL.
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Lukaszuk K, Plociennik L, Lukaszuk A, Dialobrzeska D. The Heterogenity of Anti-Mullerian Hormone Depletion in Models Across Assays in 12917 Women. Poster session at American Society for Reproductive Medicine; 2015 Oct 17-21; Baltimore, Maryland
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Mamsen LS, Bøtkjær JA, Kristensen SG, Pors SE, Jeppesen JV, Kumar A, Kalra B, Ernst E, Andersen CY. O-081 High variability of molecular isoforms of AMH in follicular fluid and granulosa cells from human small antral follicles. Front Endocrinol (Lausanne). 2021 Mar 2;12:617523. doi: 10.3389/fendo.2021.617523
All Products Cited: AMH (pico) ELISA AL-124; Various AMH Isoform Assays
Mamsen LS, Munthe-Fog L, Petersen TS, Jeppesen JV, Møllgård K, Grøndahl ML, Larsen A, Ernst E, Oxvig C, Kumar A, Kalra B, Andersen CY. Reply: Methodological considerations in measuring different AMH splice forms using ELISA: validity of proAMH ELISA. Mol Hum Reprod. 2016 May;22(5):374-5.
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Marquez K, Hoyos LR. Serum levels of anti-Mullerian hormone (AMH): More than meets the eye. F&S Reports. 2024 Feb 19; S2666-3341(24)00039-4. doi: 10.1016/j.xfre.2024.02.010.
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Marsh EE, Bernardi LA, Steinberg ML, de Chavez PJ, Visser JA, Carnethon MR, Baird DD. Novel correlates between antimullerian hormone and menstrual cycle characteristics in African-American women (23–35 years-old). Fertil Steril. 2016 Apr 23. pii: S0015-0282(16)61100-7. Epub ahead of print.
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McLennan IS, Koishi K, Batchelor NJ, Pankhurst MW. Mice with either diminished or elevated levels of anti-Müllerian hormone have decreased litter sizes. Biol Reprod. 2018 Jan 1;98(1):54-62. doi: 10.1093/biolre/iox151. PMID: 29177503.
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Meczekalski B, Czyzyk A, Kunicki M, Podfigurna-Stopa A, Plociennik L, Jakiel G, Maciejewska-Jeske M, Lukaszuk K. Fertility in women of late reproductive age: the role of serum anti-Müllerian hormone (AMH) levels in its assessment. J Endocrinol Invest. 2016 Nov;39(11):1259-1265.
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Meng L, McLuskey A, Dunaif A, Visser JA. Functional analysis of rare anti-Müllerian hormone protein-altering variants identified in women with PCOS. Mol Hum Reprod. 2023;29(5). doi:10.1093/molehr/gaad011.
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Moolhuijsen L, Meun C, Louwers Y, Broer L, Uitterlinden A, Laven J, Visser J, MON-208 Association Study of AMH Promoter Polymorphisms and Serum AMH Levels in PCOS Patients, Journal of the Endocrine Society, Volume 3, Issue Supplement_1, April-May 2019, MON–208, https://doi.org/10.1210/js.2019-MON-208
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Moolhuijsen LME, Louwers YV, Laven JSE, Visser JA. Comparison of 3 Different AMH Assays With AMH Levels and Follicle Count in Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3714-e3722. doi: 10.1210/clinem/dgac370. PMID: 35737957. PMCID: PMC9387710.
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Moolhuijsen LME, Louwers YV, Laven JSE, Visser JA. Comparison of 3 Different AMH Assays With AMH Levels and Follicle Count in Women With Polycystic Ovary Syndrome.Poster Session at the 1st European Symposium on Animal Reproduction, 21st – 23rd September 2023, Nantes, France
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Moolhuijsen LME, Louwers YV, McLuskey A, Broer L, Uitterlinden AG, Verdiesen RMG, Sisk RK, Dunaif A, Laven JSE, Visser JA. Association between an AMH promoter polymorphism and serum AMH levels in PCOS patients. Human Reproduction, 2022, deac082, https://doi.org/10.1093/humrep/deac082
All Products Cited: AMH (pico) ELISA AL-124
Moolhuijsen LME, Visser JA. Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3361–73. doi: 10.1210/clinem/dgaa513. PMID: 32770239; PMCID: PMC7486884
All Products Cited: AMH ELISA AL-105; AMH (pico) ELISA AL-124
Moolhuijsen LME, Visser JA. . Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3361-3373. doi: 10.1210/clinem/dgaa513
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Morse H. Anti-Müllerian hormone as a marker of ovarian reserve in girls before, during and after treatment for childhood cancer. [Dissertation, 2017]. Lund (Sweden): Lund University.
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Nichols H, Baird D, Stanczyk F. Anti-Müllerian Hormone Concentrations in Premenopausal Women and Breast Cancer Risk. Cancer Prevention Research. 2015 April 14 epub ahead of print.
All Products Cited: AMH ELISA AL-105; AMH (pico) ELISA AL-124
Oktay KH, Bedoschi G, Goldfarb SB, Taylan E, Titus S, Palomaki GE, Cigler T, Robson M, Dickler MN. . Increased chemotherapy-induced ovarian reserve loss in women with germline BRCA mutations due to oocyte deoxyribonucleic acid double strand break repair deficiency. Fertil Steril. 2020 Jun;113(6):1251-1260.e1. doi: 10.1016/j.fertnstert.2020.01.033
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Oktay KH, Turan V, Bedoschi G, Abdo N, Bang H, Goldfarb S. A prospective longitudinal analysis of the predictors of amenorrhea after breast cancer chemotherapy: Impact of BRCA pathogenic variants. Cancer Med. 2023 Sep;12(18):19225-19233. doi: 10.1002/cam4.6527. Epub 2023 Sep 12. PMID: 37698031; PMCID: PMC10557848.
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Pankhurst MW, Leathart BL, Batchelor NJ, McLennan IS. The Anti-Müllerian Hormone Precursor (proAMH) Is Not Converted to the Receptor-Competent Form (AMHN,C) in the Circulating Blood of Mice. Endocrinology. 2016 Apr;157(4):1622-9. Epub 2016 Feb 1.
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Pilsgaard F, Grynnerup AG, Løssl K, Bungum L, Pinborg A. The use of anti-Müllerian hormone for controlled ovarian stimulation in assisted reproductive technology, fertility assessment and -counseling. Acta Obstet Gynecol Scand. 2018 Feb 24.
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Purdue-Smithe AC, Whitcomb BW, Manson JE, Hankinson SE, Troy LM, Rosner BA, Bertone-Johnson ER. . Vitamin D Status Is Not Associated with Risk of Early Menopause. J Nutr. 2018 Sep 1;148(9):1445-1452. doi: 10.1093/jn/nxy129
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Ramezani Tehrani F, Sheidaei A, Firouzi F, Tohidi M, Azizi F, Behboudi-Gandevani S. Does the Anti-Mullerian Hormone Decline Rate Improve the Prediction of Age at Menopause?. Front Endocrinol (Lausanne). 2021 Sep 16;12:727229. doi: 10.3389/fendo.2021.727229. eCollection 2021
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Rivak P, Sachin B. Variation in the Measurement of Anti-Müllerian Hormone – What Are the Laboratory Issues?. Front Endocrinol (Lausanne). 2021 Sep 3;12:719029. doi: 10.3389/fendo.2021.719029
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Robertson DM, Kumar A, Kalra B, Shah S, Pruysers E, Vanden Brink H, Chizen D, Visser JA, Themmen AP, Baerwald A. Detection of serum antimüllerian hormone in women approaching menopause using sensitive antimüllerian hormone enzyme-linked immunosorbent assays. Menopause. 2014 Dec; 21(12):1277-86.
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Robertson DM, Lee CH, Baerwald A. Interactions between serum FSH, inhibin B and antral follicle count in the decline of serum AMH during the menstrual cycle in late reproductive age. Endocrinol Diabetes Metab. 2020 Aug 8;4(2):e00172. doi: 10.1002/edm2.172. PMID: 33855196; PMCID: PMC8029535.
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Rodriguez-Purata J, Luna M, Cervantes E, Lee J, Whitehouse M, Copperman A, Bandler B. Very Low Levels of Anti-Mullerian Hormone (AMH) in a Large Cohort of ART Patients. Poster session at American Society for Reproductive Medicine; 2015 Oct 17-21; Baltimore, Maryland
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Rudnicka E, Kunicki M, Calik-Ksepka A, Suchta K, Duszewska A, Smolarczyk K, Smolarczyk R. Anti-Müllerian hormone in pathogenesis, diagnostic and treatment of PCOS. Int J Mol Sci. 2021;22(12507):1-12. doi:10.3390/ijms222212507.
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Ruth KS, Soares ALG, Borges MC, Eliassen AH, Hankinson SE, Jones ME, Kraft P, Nichols HB, Sandler DP, Schoemaker MJ, Taylor JA, Zeleniuch-Jacquotte A, Lawlor DA, Swerdlow AJ, Murray A. Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan. Hum Mol Genet. 2019 Apr 15;28(8):1392-1401. doi: 10.1093/hmg/ddz015
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Saito A, Akira I, Tomoko N, Satoko O, Bayasula, Tomohiko M, Nao K, Chiharu I, Sachiko T, Maki G, Fumitaka K. Involvement of mesosalpinx in endometrioma is a possible risk factor for decrease of ovarian reserve after cystectomy: a retrospective cohort study. Saito et al. Reproductive Biology and Endocrinology (2016) 14:72 DOI 10.1186/s12958-016-0210-9
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Santoro N, Kuhn K, Pretzel S, et al. A high-fat eucaloric diet induces reprometabolic syndrome of obesity in normal weight women. PNAS Nexus. 2024 Dec 18; pgad440. doi: 10.1093/pnasnexus/pgad440.
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Schon S, Jiang C, Ferrell EL, Valbuena F, Neff L, Carnethon M, Marsh EE. Obesity and adiposity are associated with decreased Anti-Mullerian hormone (AMH) levels in a reproductive-aged Latina/LatinX population. J Endocr Soc. 2023;7(Supplement_1). doi:10.1210/jendso/bvad114.1616.
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Shamsa A, Gilchrist RB, Robertson DM, et al. Oocyte-secreted serum biomarkers GDF9 and BMP15 in women with endometriosis. Reprod Sci. 2023;30(3):1521-7. doi: 10.1007/s43032-022-01107-6.
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Shandley LM, Fothergill A, Spencer JB, Mertens AC, Cottrell HN, Howards PP. Impact of cancer treatment on risk of infertility and diminished ovarian reserve in women with polycystic ovary syndrome. Fertil Steril. 2018 Mar;109(3):516-525.e1.
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Shankara-Narayana N, Yu C, Savkovic S, Desai R, Fennell C, Turner L, Jayadev V, Conway AJ, Kockx M, Ridley L, Kritharides L, Handelsman DJ. Rate and Extent of Recovery from Reproductive and Cardiac Dysfunction Due to Androgen Abuse in Men. J Clin Endocrinol Metab. 2020 Jun 1;105(6):dgz324. doi: 10.1210/clinem/dgz324. PMID: 32030409.
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Sivanandy MS, Ha SK. The role of serum Anti-Mullerian hormone measurement in the diagnosis of polycystic ovary syndrome. Diagnostics (Basel). 2023;13(907):1-12. doi:10.3390/diagnostics13050907.
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Steiner AZ. AMH as a Predictor of the Final Menstrual Period. J Clin Endocrinol Metab. April 1;105(4):e1908–e1909. https://doi.org/10.1210/clinem/dgaa025
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Straseski J, Lu J, Holt C, Choi M, Kalp K. Analytical Evaluation of the Ansh Labs picoAMH ELISA assay for Anti-Mullerian Hormone. Poster session presented at the 96th Annual Endocrine Society Meeting; 2014 Jun 21-24; Chicago, IL.
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Su HI, Sammel MD, Homer MV, Bui K, Haunschild C, Stanczyk FZ. Comparability of antimüllerian hormone levels among commercially available immunoassays. Fertility and Sterility. 2014 Jun; 101(6):1766-72.e1.
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Toribio M, Neilan TG, Awadalla M, Stone LA, Rokicki A, Rivard C, Mulligan CP, Cagliero D, Fourman LT, Stanley TL, Ho JE, Triant VA, Burdo TH, Nelson MD, Szczepaniak LS, Zanni MV. Intramyocardial Triglycerides Among Women With vs Without HIV: Hormonal Correlates and Functional Consequences. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6090-6100. doi: 10.1210/jc.2019-01096. PMID: 31393564; PMCID: PMC6954489.
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Upson K, Chin HB, Marsh EE, Baird DD. Intrauterine, Infant, and Childhood Factors and Ovarian Reserve in Young African American Women. J Womens Health (Larchmt). 2019 Dec;28(12):1711-1720. doi: 10.1089/jwh.2018.7382
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Verdiesen RM, van der Schouw YT, van Gils CH, et al. Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women. medRxiv. 2020 Nov 3;2020.10.29.20221390. doi: 10.1101/2020.10.29.20221390
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Verdiesen RMG, Onland-Moret NC, van Gils CH, Stellato RK, Spijkerman AMW, Picavet HSJ, Broekmans FJM, Verschuren WMM, van der Schouw YT. Anti-Müllerian hormone levels and risk of type 2 diabetes in women. Diabetologia. 2021 Feb;64(2):375-384. doi: 10.1007/s00125-020-05302-5. Epub 2020 Oct 13. PMID: 33048171; PMCID: PMC7801305.
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Welsh P, Smith K, Nelson SM. A single-centre evaluation of two new Anti-Mullerian Hormone assays and comparison with the current clinical standard assay. Human Reproduction. 2014 May; 29(5):1035-41.
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Whitcomb BW, Purdue-Smithe A, Hankinson SE, Manson JE, Rosner BA, Bertone-Johnson ER. Menstrual Cycle Characteristics in Adolescence and Early Adulthood Are Associated With Risk of Early Natural Menopause. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3909-3918. doi: 10.1210/jc.2018-01110. PMID: 30060103; PMCID: PMC6179161.
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White A, Sandler D, D’Aloisio A, Stanczyk F, Whitworth K, Baird D, Nichols H. Anti-Mullerian hormone (AMH) in relation to tobacco and marijuana use and sources of indoor heating/cooking. Fertility and Sterility. First published online May 27, 2016.
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Wise LA, Wang TR, Mikkelsen EM, Wesselink AK, Calafat AM, Wegienka G, Geller RJ, Coleman CM, Willis MD, Marsh EE, Schildroth S, Botelho JC, Messerlian-Lambert G, Hatch EE. Per- and Polyfluoroalkyl Substances and Anti-Müllerian Hormone Concentrations in Two Preconception Cohort Studies. Environ Health Perspect. 2023 Oct;131(10):107703. doi: 10.1289/EHP12592. Epub 2023 Oct 26. PMID: 37882725; PMCID: PMC10601879.
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Xu H, Zhang M, Zhang H, Alpadi K, Wang L, Li R, Qiao J. Clinical Applications of Serum Anti-Müllerian Hormone Measurements in Both Males and Females: An Update. Innovation (Camb). 2021 Feb 9;2(1):100091. doi: 10.1016/j.xinn.2021.100091. PMID: 34557745; PMCID: PMC8454570.
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Xu H, Zhang M, Zhang H, Alpadi K, Wang L, Li R, Qiao J. Clinical Applications of Serum Anti-Mullerian Hormone Measurements in Both Males and Females: An Update. Innovation (N Y). 2021 Feb 9;2(1):100091. doi: 10.1016/j.xinn.2021.100091
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