| Catalog Number | AB-306-AI005 |
|---|---|
| Packaging | 100 µg |
| Shipping Conditions | This product is shipped on dry ice. Upon receipt, store it immediately at the recommended temperature. |
| Application(s) | ELISA, IHC, WB |
| Source | Murine |
| Product Appearance | Clear, Colorless solution |
| Ab Type | Monoclonal Antibody |
| Isotype | IgG1 |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | BetaB Peptide |
| Purification | Purified from hybridoma culture supernatant using Protein G. |
| Activity | Determined by direct ELISA |
| Composition | Phosphate Buffered Saline, 10mM, pH 7.4 (No Preservatives) |
| Storage | Store at -20°C to -80°C as supplied. Avoid repeated freeze-thaw cycles |
| Availability | Worldwide |
| Regulatory Status | For Research Use Only. Not for use in diagnostic or therapeutic procedures. |
| Epitopes and Specificity | Inhibin BetaBSubunit |
Conover CA, Bale LK, Frye RL, Schaff HV. Cellular characterization of human epicardial adipose tissue:highly
expressed PAPP-A regulates insulin-like growth factor I signaling in human cardiomyocytes. Physiol Rep.
2019;7(4):e14006. doi:10.14814/phy2.14006.
Jana A, Das A, Krett NL, Guzman G, Thomas A, Mancinelli G, Bauer J, Ushio-Fukai M, Fukai T, Jung B. Nuclear
translocation of Atox1 potentiates activin A-induced cell migration and colony formation in colon cancer. PLoS
One. 2020 Jan 21;15(1):e0227916. doi: 10.1371/journal.pone.0227916.
Lambert-Messerlian G, Steinhoff M, Kumar A, Eklund EE, Moore R. Comparison of Inhibin Alpha Subunit and
Antimüllerian Hormone Immunoreactivity in Granulosa Cell and Mucinous Ovarian Tumors. Appl
Immunohistochem Mol Morphol. 2017 Jan;25(1):71-77. doi: 10.1097/PAI.0000000000000251.
Lilja-Maula L, Syrjä P, Laurila HP, Sutinen E, Palviainen M, Ritvos O, Koli K, Rajamäki MM, Myllärniemi M.
Upregulation of alveolar levels of activin B, but not activin A, in lungs of west highland white terriers with
idiopathic pulmonary fibrosis and diffuse alveolar damage. J Comp Pathol. 2015 Feb-Apr;152(2-3):192-200. doi:
10.1016/j.jcpa.2014.11.006.
Mancinelli G, Torres C, Krett N, Bauer J, Castellanos K, McKinney R, Dawson D, Guzman G, Hwang R, Grimaldo
S, Grippo P, Jung B. Role of stromal activin A in human pancreatic cancer and metastasis in mice. Sci Rep. 2021
Apr 12;11(1):7986. doi: 10.1038/s41598-021-87213-y.
Myllärniemi M, Tikkanen J, Hulmi JJ, Pasternack A, Sutinen E, Rönty M, Leppäranta O, Ma H, Ritvos O, Koli K.
Upregulation of activin-B and follistatin in pulmonary fibrosis – a translational study using human biopsies and a
specific inhibitor in mouse fibrosis models. BMC Pulm Med. 2014 Nov 1;14:170. doi: 10.1186/1471-2466-14-170.
Tamminen JA, Yin M, Rönty M, Sutinen E, Pasternack A, Ritvos O, Myllärniemi M, Koli K. Overexpression of
activin-A and -B in malignant mesothelioma – attenuated Smad3 signaling responses and ERK activation promote
cell migration and invasive growth. Exp Cell Res. 2015 Mar 1;332(1):102-15. doi: 10.1016/j.yexcr.2014.12.010.
Thomas AL, Castellanos K, Mancinelli G, Xia Y, Bauer J, Yazici C, Fantuzzi G, Hwang RF, Krett NL, Papachristou
GI, Whitcomb DC, Jung B. Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe
Disease Independent of Body Mass Index. Clin Transl Gastroenterol. 2020 May;11(5):e00152. doi: 10.14309/
ctg.0000000000000152.