The Rat and Mouse Activin B enzyme linked immunuosorbent assay (ELISA) kit provides materials for the quantitative measurement of Activin B in rat and mouse serum and other biological fluids.
| Catalog Number | |
|---|---|
| Packaging | 96 well microtiter |
| Detection | HRP-based ELISA, colorimetric detection by dual wavelength absorbance at 450 nm and 630 nm as reference filter |
| Dynamic Range | 6, 20 – 2000 pg/mL |
| Limit of Detection | 5.28 pg/mL |
| Sample Size | 50 µL |
| Sample Type | Serum |
| Assay Time | 3.5 hours |
| Shelf Life | 24 months |
| Species Reactivity | Murine Serum, Rabbit Serum, Rattus Serum, Vervet Monkey Serum |
| Availability | Worldwide |
Activins, like all members of the transforming growth factor-beta superfamily, are synthesized as large pro-hormones with N-terminal pro- and C-terminal mature domains. Studies have shown that the prodomains template the dimerization of pro-activin forms, that are subsequently processed to yield pro/mature fragments. The prodomains, although important for folding and extracellular localization, must be removed prior to activity. Activin forms retaining the prodomain are biologically inactive.
Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.
Activin B exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands.
Activin B (Mouse) ELISA AL-156
Palin NK, Savikko J, Pasternack A, Rintala JM, Kalra B, Mistry S, Kumar A, Roth MP, Helin H, Ritvos O. Activin inhibition limits early innate immune response in rat kidney allografts-a pilot study. Transpl Int. 2017 Jan;30(1):96-107. doi: 10.1111/tri.12876. Epub 2016 Nov 23. PMID: 27732750.
All Products Cited: Activin B (Mouse) ELISA AL-156; Activin A ELISA AL-110
Rodriguez KF, Brown PR, Amato CM, Nicol B, Liu CF, Xu X, Yao HH. Somatic cell fate maintenance in mouse fetal testes via autocrine/paracrine action of AMH and activin B. Nat Commun. 2022;13(4130):1-12. doi:10.1038/s41467-022-31486-y.
All Products Cited: AMH (Rat/Mouse) ELISA AL-113; Activin B (Mouse) ELISA AL-156